SDF1-CXCR4 Signaling Maintains Central Post-Stroke Pain through Mediation of Glial-Neuronal Interactions

SDF1-CXCR4 Signaling Maintains Central Post-Stroke Pain through Mediation of Glial-Neuronal Interactions

Central post-stroke pain (CPSP) is an intractable central neuropathic pain that has been poorly studied mechanistically. Here we showed that stromal cell-derived factor 1 (SDF1 or CXCL12), a member of the CXC chemokine family, and its receptor CXCR4 played a key role in the development and maintenan...

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Bibliographic Details
Main Authors: Fei Yang, Wen-Jun Luo, Wei Sun, Yan Wang, Jiang-Lin Wang, Fan Yang, Chun-Li Li, Na Wei, Xiao-Liang Wang, Su-Min Guan, Jun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
central post-stroke pain
intra-thalamic injection
mechanical pain hypersensitivity
SDF1-CXCR4 signaling
hypoxia inducible factor 1α
glial-neuronal crosstalk
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00226/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00226/full

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