Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection

Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection

Porcine reproductive and respiratory syndrome virus (PRRSV) 1 and 2 differ in their recognition of CD163. Substitution of porcine CD163 SRCR5 domain with a human CD163-like SRCR8 confers resistance to PRRSV 1 but not PRRSV 2. The deletion of CD163 SRCR5 has been shown to confer resistance to PRRSV 1...

Full description

Bibliographic Details
Main Authors: Chunhe Guo, Min Wang, Zhenbang Zhu, Sheng He, Hongbo Liu, Xiaofeng Liu, Xuan Shi, Tao Tang, Piao Yu, Jianhua Zeng, Linfang Yang, Yongchang Cao, Yaosheng Chen, Xiaohong Liu, Zuyong He
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
PRRSV
CD163
SRCR5
CRISPR/Cas9
resistance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01846/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01846/full

Similar Items