Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection
Porcine reproductive and respiratory syndrome virus (PRRSV) 1 and 2 differ in their recognition of CD163. Substitution of porcine CD163 SRCR5 domain with a human CD163-like SRCR8 confers resistance to PRRSV 1 but not PRRSV 2. The deletion of CD163 SRCR5 has been shown to confer resistance to PRRSV 1...
Main Authors: | Chunhe Guo, Min Wang, Zhenbang Zhu, Sheng He, Hongbo Liu, Xiaofeng Liu, Xuan Shi, Tao Tang, Piao Yu, Jianhua Zeng, Linfang Yang, Yongchang Cao, Yaosheng Chen, Xiaohong Liu, Zuyong He |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-08-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01846/full |
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