Sample size calculation in multi-centre clinical trials

Sample size calculation in multi-centre clinical trials

Abstract Background Multi-centre randomized controlled clinical trials play an important role in modern evidence-based medicine. Advantages of collecting data from more than one site are numerous, including accelerated recruitment and increased generalisability of results. Mixed models can be applie...

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Bibliographic Details
Main Authors: Markus Harden, Tim Friede
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Medical Research Methodology
Subjects:
Block randomisation
Linear mixed model
Random effects
Online Access:http://link.springer.com/article/10.1186/s12874-018-0602-y

Internet

http://link.springer.com/article/10.1186/s12874-018-0602-y

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