Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy

Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy

ADAM17 is a disintegrin and metalloproteinase capable of cleaving the ectodomains of a diverse variety of molecules including TNF-α, TGF-α, L-selectin, and ACE2. We have previously demonstrated that renal ADAM17 is upregulated in diabetic mice. The role of endothelial (<i>eAdam17</i>) an...

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Bibliographic Details
Main Authors: Vanesa Palau, Bramasta Nugraha, David Benito, Julio Pascual, Maximilian Y. Emmert, Simon P. Hoerstrup, Marta Riera, Maria José Soler
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
ADAM17
diabetic nephropathy
endothelial deletion
renal proximal tubular deletion
3D proximal tubular spheroids
Online Access:https://www.mdpi.com/1422-0067/22/11/5520

Internet

https://www.mdpi.com/1422-0067/22/11/5520

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