FXR-mediated down-regulation of CYP7A1 dominates LXRα in long-term cholesterol-fed NZW rabbits

FXR-mediated down-regulation of CYP7A1 dominates LXRα in long-term cholesterol-fed NZW rabbits

We investigated how cholesterol feeding regulates cholesterol 7α-hydroxylase (CYP7A1) via the nuclear receptors farnesoid X receptor (FXR) and liver X receptor α (LXRα) in New Zealand white rabbits. After 1 day of 2% cholesterol feeding, when the bile acid pool size had not expanded, mRNA levels of...

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Bibliographic Details
Main Authors: Guorong Xu, Hai Li, Lu-xing Pan, Quan Shang, Akira Honda, M. Ananthanarayanan, Sandra K. Erickson, Benjamin L. Shneider, Sarah Shefer, Jaya Bollineni, Barry M. Forman, Yasushi Matsuzaki, Frederick J. Suchy, G. Stephen Tint, Gerald Salen
Format: Article
Language:English
Published: Elsevier 2003-10-01
Series:Journal of Lipid Research
Subjects:
dietary cholesterol
oxysterol
short-heterodimer partner
ATP binding cassette transporter A1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337135

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http://www.sciencedirect.com/science/article/pii/S0022227520337135

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