Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans

Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans

Background and Aims: Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR, on overall plaque vulnerability, plaque phenotype, intraplaque OSMR and LIFR expre...

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Bibliographic Details
Main Authors: Danielle van Keulen, Ian D. van Koeverden, Arjan Boltjes, Hans M. G. Princen, Alain J. van Gool, Gert J. de Borst, Folkert W. Asselbergs, Dennie Tempel, Gerard Pasterkamp, Sander W. van der Laan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiovascular disease
atherosclerosis
plaque
genetics
OSM
OSMR
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.658915/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.658915/full

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