Diagnostic Leukapheresis Enables Reliable Transcriptomic Profiling of Single Circulating Tumor Cells to Characterize Inter-Cellular Heterogeneity in Terms of Endocrine Resistance

Diagnostic Leukapheresis Enables Reliable Transcriptomic Profiling of Single Circulating Tumor Cells to Characterize Inter-Cellular Heterogeneity in Terms of Endocrine Resistance

Circulating tumor cells (CTCs) hold great promise with regard to prognosis, treatment optimization, and monitoring of breast cancer patients. Single CTC transcriptome profiling might help reveal valuable information concerning intra-patient heterogeneity relevant to therapeutic interventions. In thi...

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Bibliographic Details
Main Authors: Florian Reinhardt, André Franken, Franziska Meier-Stiegen, Christiane Driemel, Nikolas H. Stoecklein, Johannes C. Fischer, Dieter Niederacher, Eugen Ruckhaeberle, Tanja Fehm, Hans Neubauer
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
breast cancer
liquid biopsy
diagnostic leukapheresis
DLA
circulating tumor cells
CTC
single cell profiling
transcriptomic profiling
RT-qPCR
Online Access:https://www.mdpi.com/2072-6694/11/7/903

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https://www.mdpi.com/2072-6694/11/7/903

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