Cocaine Self-administration and Extinction Inversely Alter Neuron to Glia Exosomal Dynamics in the Nucleus Accumbens

Cocaine Self-administration and Extinction Inversely Alter Neuron to Glia Exosomal Dynamics in the Nucleus Accumbens

Alteration of glutamatergic synaptic plasticity in the Nucleus Accumbens (NAc) has been implicated in cocaine-seeking behaviors. Astroglial mechanisms for maintaining extracellular glutamate homeostasis through cysteine/glutamate exchanger (xCT) and glutamate transporter GLT1 are dysregulated follow...

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Bibliographic Details
Main Authors: Rachel Jarvis, Alessandra Tamashiro-Orrego, Vanessa Promes, Leona Tu, Jinyuan Shi, Yongjie Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cocaine
exosome
astroglia
GLT1
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00581/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00581/full

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