Frequency of off-targeting in genome edited pigs produced via direct injection of the CRISPR/Cas9 system into developing embryos

Frequency of off-targeting in genome edited pigs produced via direct injection of the CRISPR/Cas9 system into developing embryos

Abstract Background The CRISPR/Cas9 system can effectively introduce site-specific modifications to the genome. The efficiency is high enough to induce targeted genome modifications during embryogenesis, thus increasing the efficiency of producing genetically modified animal models and having potent...

Full description

Bibliographic Details
Main Authors: Kayla Carey, Junghyun Ryu, Kyungjun Uh, Andrea J. Lengi, Sherrie Clark-Deener, Benjamin A. Corl, Kiho Lee
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Biotechnology
Subjects:
CRISPR/Cas9
Off-targeting
Genome-editing
Embryo development
Online Access:http://link.springer.com/article/10.1186/s12896-019-0517-7

Internet

http://link.springer.com/article/10.1186/s12896-019-0517-7

Similar Items