Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation.
Hypoxia-inducible factor (HIF) is a nuclear transcription factor that responds to environmental and pathological hypoxia to induce metabolic adaptation, vascular growth, and cell survival. Here we found that HIF subunits and HIF2α in particular were normally expressed in the mediobasal hypothalamus...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-07-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC3144184?pdf=render |