Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

Li et al. investigates the role of N-linked glycosylation for the function of mechanosensitive ion channel Piezo1. They show that disease-linked loss of function mutations in Piezo1 that are trafficking defective lack N-linked glycosylation.

Bibliographic Details
Main Authors: Jinyuan Vero Li, Chai-Ann Ng, Delfine Cheng, Zijing Zhou, Mingxi Yao, Yang Guo, Ze-Yan Yu, Yogambha Ramaswamy, Lining Arnold Ju, Philip W. Kuchel, Michael P. Feneley, Diane Fatkin, Charles D. Cox
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02528-w

Internet

https://doi.org/10.1038/s42003-021-02528-w

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