Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

Here, the authors compare the crystal structures and investigate the neutralization mechanisms of three neutralizing antibodies against SARS-CoV-2 and find that one antibody, P2C-1F11, closely mimics binding of receptor ACE2 and displays the most potent neutralizing activity in vitro, as well as con...

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Bibliographic Details
Main Authors: Jiwan Ge, Ruoke Wang, Bin Ju, Qi Zhang, Jing Sun, Peng Chen, Senyan Zhang, Yuling Tian, Sisi Shan, Lin Cheng, Bing Zhou, Shuo Song, Juanjuan Zhao, Haiyan Wang, Xuanling Shi, Qiang Ding, Lei Liu, Jincun Zhao, Zheng Zhang, Xinquan Wang, Linqi Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20501-9

Internet

https://doi.org/10.1038/s41467-020-20501-9

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