Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis

Short Chain Fatty Acid Acetate Increases TNFα-Induced MCP-1 Production in Monocytic Cells via ACSL1/MAPK/NF-κB Axis

Short-chain fatty acid (SCFA) acetate, a byproduct of dietary fiber metabolism by gut bacteria, has multiple immunomodulatory functions. The anti-inflammatory role of acetate is well documented; however, its effect on monocyte chemoattractant protein-1 (MCP-1) production is unknown. Similarly, the c...

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Bibliographic Details
Main Authors: Areej Al-Roub, Nadeem Akhter, Amnah Al-Sayyar, Ajit Wilson, Reeby Thomas, Shihab Kochumon, Fatema Al-Rashed, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
short-chain fatty acids
acetate
TNFα
THP-1 monocytic cells
MCP-1
NF-κB
Online Access:https://www.mdpi.com/1422-0067/22/14/7683

Internet

https://www.mdpi.com/1422-0067/22/14/7683

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