Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate Cancer

Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate Cancer

2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), a synthetic analog of oleanolic acid, and its C28 methyl ester derivative (CDDO-Me), have shown potent antitumorigenic activity against a wide range of cancer cell lines, including prostate cancer cells in vitro, and inhibited the development...

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Bibliographic Details
Main Authors: Subhash C. Gautam, Scott A. Dulchavsky, George W. Divine, Ali S. Arbab, Yongbo Liu, Xiaohua Gao, Dorrah Deeb
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Cancers
Subjects:
prostate cancer
chemoprevention
CDDO-Me
apoptosis
Akt/mTOR/NF-kB signaling
Online Access:http://www.mdpi.com/2072-6694/3/3/3353/

Internet

http://www.mdpi.com/2072-6694/3/3/3353/

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