Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia

Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia

Therapeutic hypothermia represents a brain-protective strategy for multiple emergency situations, such as stroke or traumatic injury. Neurotensin (NT), which exerts its effects through activation of two G protein-coupled receptors, namely NTS1 and NTS2, induces a strong and long-lasting decrease in...

Full description

Bibliographic Details
Main Authors: Santo Previti, Mélanie Vivancos, Emmanuelle Rémond, Sabrina Beaulieu, Jean-Michel Longpré, Steven Ballet, Philippe Sarret, Florine Cavelier
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Chemistry
Subjects:
NTS1
reduced peptide bonds
unnatural amino acids
proteolytic stability
hypothermia
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00406/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00406/full

Similar Items