Diastereomeric Recognition of 5’,8-cyclo-2’-Deoxyadenosine Lesions by Human Poly(ADP-ribose) Polymerase 1 in a Biomimetic Model

Diastereomeric Recognition of 5’,8-cyclo-2’-Deoxyadenosine Lesions by Human Poly(ADP-ribose) Polymerase 1 in a Biomimetic Model

5&#8217;,8-Cyclo-2&#8217;-deoxyadenosine (cdA), in the 5&#8217;<i>R</i> and 5&#8217;<i>S</i>diastereomeric forms, are typical non strand-break oxidative DNA lesions, induced by hydroxyl radicals, with emerging importance as a molecular marker. These lesions ar...

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Bibliographic Details
Main Authors: Annalisa Masi, Arianna Sabbia, Carla Ferreri, Francesco Manoli, Yanhao Lai, Eduardo Laverde, Yuan Liu, Marios G. Krokidis, Chryssostomos Chatgilialoglu, Maria Rosaria Faraone Mennella
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
human poly(ADP-ribose) polymerase 1 (PARP1)
PARP-DNA complex
DNA-protein binding
DNA repair
5’,8-Cyclopurine-2’-deoxynucleoside
DNA damage
DNA repair efficiency
Online Access:https://www.mdpi.com/2073-4409/8/2/116

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https://www.mdpi.com/2073-4409/8/2/116

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