Stimulation of the Epithelial Na+ Channel in Renal Principal Cells by Gs-Coupled Designer Receptors Exclusively Activated by Designer Drugs

Stimulation of the Epithelial Na+ Channel in Renal Principal Cells by Gs-Coupled Designer Receptors Exclusively Activated by Designer Drugs

The activity of the Epithelial Na+ Channel (ENaC) in renal principal cells (PC) fine-tunes sodium excretion and consequently, affects blood pressure. The Gs-adenylyl cyclase-cAMP signal transduction pathway is believed to play a central role in the normal control of ENaC activity in PCs. The current...

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Bibliographic Details
Main Authors: Antonio G. Soares, Jorge Contreras, Crystal R. Archer, Elena Mironova, Rebecca Berdeaux, James D. Stockand, Tarek Mohamed Abd El-Aziz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
vasopressin
sodium excretion
sodium transport
hypertension
epithelial sodium channel
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.725782/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.725782/full

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