Improved anticancer drug response prediction in cell lines using matrix factorization with similarity regularization

Abstract Background Human cancer cell lines are used in research to study the biology of cancer and to test cancer treatments. Recently there are already some large panels of several hundred human cancer cell lines which are characterized with genomic and pharmacological data. The ability to predict...

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Bibliographic Details
Main Authors: Lin Wang, Xiaozhong Li, Louxin Zhang, Qiang Gao
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Cancer
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12885-017-3500-5