Inhibition of Dephosphorylation of Dolichyl Diphosphate Alters the Synthesis of Dolichol and Hinders Protein <i>N</i>-Glycosylation and Morphological Transitions in <i>Candida albicans</i>

Inhibition of Dephosphorylation of Dolichyl Diphosphate Alters the Synthesis of Dolichol and Hinders Protein <i>N</i>-Glycosylation and Morphological Transitions in <i>Candida albicans</i>

The essential role of dolichyl phosphate (DolP) as a carbohydrate carrier during protein <i>N</i>-glycosylation is well established. The cellular pool of DolP is derived from de novo synthesis in the dolichol branch of the mevalonate pathway and from recycling of DolPP after each cycle o...

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Bibliographic Details
Main Authors: Anna Janik, Monika Niewiadomska, Urszula Perlińska-Lenart, Jacek Lenart, Damian Kołakowski, Karolina Skorupińska-Tudek, Ewa Swiezewska, Joanna S. Kruszewska, Grażyna Palamarczyk
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
<i>c. albicans</i>
cell wall integrity
cwh8p
dolichol
morphogenesis
rer2p
Online Access:https://www.mdpi.com/1422-0067/20/20/5067

Internet

https://www.mdpi.com/1422-0067/20/20/5067

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