LincRNA Plays a Role in the Effect of CYP46A1 Polymorphism in Alzheimer’s Disease – Related Pathology

Polymorphism of the cholesterol-24S-hydroxylase (CYP46A1) gene is thought to be a risk factor for Alzheimer’s disease (AD). A single nucleotide polymorphism (T/C) in intron 2, rs754203, has been confirmed to be implicated in AD. Rs754203 is located in the long intronic non-coding RNA (LincRNA) seque...

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Bibliographic Details
Main Authors: Yang Chen, Hui-Yun Li, Fan Zeng, Le Chen, Fa-Ying Zhou, Ze-Yan Peng, Hai Yang, Hua-Dong Zhou, Yan-Jiang Wang, Ling Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00381/full