Structure of the human ClC-1 chloride channel.

Structure of the human ClC-1 chloride channel.

ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, we present the cryo-electron microscopy (cryo-EM) s...

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Bibliographic Details
Main Authors: Kaituo Wang, Sarah Spruce Preisler, Liying Zhang, Yanxiang Cui, Julie Winkel Missel, Christina Grønberg, Kamil Gotfryd, Erik Lindahl, Magnus Andersson, Kirstine Calloe, Pascal F Egea, Dan Arne Klaerke, Michael Pusch, Per Amstrup Pedersen, Z Hong Zhou, Pontus Gourdon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000218

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https://doi.org/10.1371/journal.pbio.3000218

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