Tregitopes Improve Asthma by Promoting Highly Suppressive and Antigen-Specific Tregs

Tregitopes Improve Asthma by Promoting Highly Suppressive and Antigen-Specific Tregs

Tregitopes (T regulatory epitopes) are IgG-derived peptides with high affinity to major histocompatibility complex class II (MHCII), that are known to promote tolerance by activating T regulatory cell (Treg) activity. Here we characterized the effect of IgG Tregitopes in a well-established murine mo...

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Bibliographic Details
Main Authors: Marieme Dembele, Shao Tao, Amir H. Massoud, S. M. Shahjahan Miah, Sandra Lelias, Anne S. De Groot, Bruce D. Mazer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
Tregitope
allergic airways disease (AAD)
adoptive transfer
T regulatory cells (Tregs)
induced Tregs (iTregs)
murine model of asthma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.634509/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.634509/full

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