Identification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole Clustering

Identification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole Clustering

A major limitation of clinically used cancer drugs is the lack of specificity resulting in toxicity. To address this, we performed a phenotypically-driven screen to identify optimal multidrug combinations acting with high efficacy and selectivity in clear cell renal cell carcinoma (ccRCC). The searc...

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Bibliographic Details
Main Authors: Andrea Weiss, Morgan Le Roux-Bourdieu, Marloes Zoetemelk, George M. Ramzy, Magdalena Rausch, Daniela Harry, Marijana Miljkovic-Licina, Katayoun Falamaki, Bernard Wehrle-Haller, Patrick Meraldi, Patrycja Nowak-Sliwinska
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
drug combinations
drug synergy
centrosome
multipolar spindle pole clustering
Online Access:https://www.mdpi.com/2072-6694/11/10/1612

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https://www.mdpi.com/2072-6694/11/10/1612

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