Blocking Autophagy in Cancer-Associated Fibroblasts Supports Chemotherapy of Pancreatic Cancer Cells

Blocking Autophagy in Cancer-Associated Fibroblasts Supports Chemotherapy of Pancreatic Cancer Cells

In this study we evaluated the interaction of pancreatic cancer cells, cancer-associated fibroblasts, and distinct drugs such as α-cyano-4-hydroxycinnamate, metformin, and gemcitabine. We observed that α-cyano-4-hydroxycinnamate as monotherapy or in combination with metformin could significantly ind...

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Bibliographic Details
Main Authors: Xianbin Zhang, Maria Schönrogge, Johanna Eichberg, Edgar Heinz Uwe Wendt, Simone Kumstel, Jan Stenzel, Tobias Lindner, Robert Jaster, Bernd Joachim Krause, Brigitte Vollmar, Dietmar Zechner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
autophagy
cancer-associated fibroblasts
gemcitabine
metformin
α-cyano-4-hydroxycinnamate
pancreatic cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00590/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00590/full

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