Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility

Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility

Abstract The Ihara epileptic rat (IER) is a mutant model with limbic-like seizures whose pathology and causative gene remain elusive. In this report, via linkage analysis, we identified Down syndrome cell adhesion molecule-like 1(Dscaml1) as the responsible gene for IER. A single base mutation in Ds...

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Bibliographic Details
Main Authors: Yoneko Hayase, Shigeru Amano, Koichi Hashizume, Takashi Tominaga, Hiroyuki Miyamoto, Yukie Kanno, Yukiko Ueno-Inoue, Takayoshi Inoue, Mayumi Yamada, Shigehiro Ogata, Shabeesh Balan, Ken Hayashi, Yoshiki Miura, Kentaro Tokudome, Yukihiro Ohno, Takuma Nishijo, Toshihiko Momiyama, Yuchio Yanagawa, Akiko Takizawa, Tomoji Mashimo, Tadao Serikawa, Akihiro Sekine, Eiji Nakagawa, Eri Takeshita, Takeo Yoshikawa, Chikako Waga, Ken Inoue, Yu-ichi Goto, Yoichi Nabeshima, Nobuo Ihara, Kazuhiro Yamakawa, Shinichiro Taya, Mikio Hoshino
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Acta Neuropathologica Communications
Subjects:
DSCAML1
Seizure susceptibility
Ihara epileptic rat
Gabaergic neurons
Patient-type model mouse
Online Access:https://doi.org/10.1186/s40478-020-01082-6

Internet

https://doi.org/10.1186/s40478-020-01082-6

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