The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling

The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling

The NG2 proteoglycan is expressed by oligodendrocyte precursor cells (OPCs) and is abundantly expressed by tumors such as melanoma and glioblastoma. Functions of NG2 include an influence on proliferation, migration and neuromodulation. Similar to other type-1 membrane proteins, NG2 undergoes proteol...

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Bibliographic Details
Main Authors: Tanmoyita Nayak, Jacqueline Trotter, Dominik Sakry
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
NG2
ICD
γ-secretase
OPC
FMRP
mTOR
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00231/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00231/full

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