The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling
The NG2 proteoglycan is expressed by oligodendrocyte precursor cells (OPCs) and is abundantly expressed by tumors such as melanoma and glioblastoma. Functions of NG2 include an influence on proliferation, migration and neuromodulation. Similar to other type-1 membrane proteins, NG2 undergoes proteol...
Main Authors: | Tanmoyita Nayak, Jacqueline Trotter, Dominik Sakry |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-08-01
|
Series: | Frontiers in Cellular Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00231/full |
Similar Items
-
Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts
by: Jasbir Singh Dalal, et al.
Published: (2021-07-01) -
Acute brain injuries trigger microglia as an additional source of the proteoglycan NG2
by: Wenhui Huang, et al.
Published: (2020-08-01) -
Regulation of mTORC1 by lysosomal calcium and calmodulin
by: Ruo-Jing Li, et al.
Published: (2016-10-01) -
mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking
by: Nadege Morisot, et al.
Published: (2019-12-01) -
Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
by: Matthew P McCabe, et al.
Published: (2020-03-01)