Does Amifostine Reduce Metabolic Rate? Effect of the Drug on Gas Exchange and Acute Ventilatory Hypoxic Response in Humans

Does Amifostine Reduce Metabolic Rate? Effect of the Drug on Gas Exchange and Acute Ventilatory Hypoxic Response in Humans

Amifostine is added to chemoradiation regimens in the treatment of many cancers on the basis that, by reducing the metabolic rate, it protects normal cells from toxic effects of therapy. We tested this hypothesis by measuring the metabolic rate (by gas exchange) over 255 min in 6 healthy subjects, a...

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Bibliographic Details
Main Authors: Jaideep J. Pandit, Caroline Allen, Evelyn Little, Federico Formenti, Adrian L. Harris, Peter A. Robbins
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Pharmaceuticals
Subjects:
hypoxia
hypercapnia
ventilation
ventilatory control
chemoreflexes
metabolism
gas exchange
hypoxia-inducible factor
Online Access:http://www.mdpi.com/1424-8247/8/2/186

Internet

http://www.mdpi.com/1424-8247/8/2/186

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