New nanocarried phenobarbital formulation: Maintains better control of pentylenetetrazole-Induced seizures

New nanocarried phenobarbital formulation: Maintains better control of pentylenetetrazole-Induced seizures

This study aims to evaluate the efficacy of slow release phenobarbital in the control of convulsions triggered by pentylenetetrazole (PTZ), verifying the time of permanence in the anticonvulsant effect through behavior and electroencephalographic records. A total of 162 male Wistar rats weighing bet...

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Bibliographic Details
Main Authors: Lorena Cristina Nunes de Almeida, Beatriz de Andrade Marques, Rafaela Laranjeira Silva, Akira Otake Hamoy, Vanessa Jóia de Mello, Rosivaldo dos Santos Borges, Frank Sales Nunes Brito, Elson Longo, Marcos Anicete-Santos, Moisés Hamoy
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biotechnology Reports
Subjects:
Phenobarbital
Anticonvulsant
Nanocarrier
Drug delivery systems
Layered double hydroxide
Online Access:http://www.sciencedirect.com/science/article/pii/S2215017X20303763

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http://www.sciencedirect.com/science/article/pii/S2215017X20303763

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