Corticotrophin-Releasing Factor Modulates Cerebellar Purkinje Cells Simple Spike Activity in Vivo in Mice

Corticotrophin-Releasing Factor Modulates Cerebellar Purkinje Cells Simple Spike Activity in Vivo in Mice

Corticotropin-releasing factor (CRF) is a major neuromodulator that modulates cerebellar neuronal activity via CRF receptors during stress responses. In the cerebellar cortex, CRF dose-dependently increases the simple spike (SS) firing rate of Purkinje cells (PCs), while the synaptic mechanisms of t...

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Bibliographic Details
Main Authors: Hong-Wei Wang, Jing-Tong Zhao, Bing-Xue Li, Shan-Shan Su, Yan-Hua Bing, Chun-Ping Chu, Wei-Ming Wang, Yu-Zi Li, De-Lai Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cerebellar Purkinje cell
in vivo whole-cell patch-clamp recording
complex spike (CS)
corticotropin-releasing factor (CRF)
miniature postsynaptic currents
simple-spike (SS)
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00184/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00184/full

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