Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response.

Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response.

The RIG-I-like receptor (RLR) pathway is essential for detecting cytosolic viral RNA to trigger the production of type I interferons (IFNα/β) that initiate an innate antiviral response. Through systematic assessment of a wide variety of genomics data, we discovered 10 molecular signatures of known R...

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Bibliographic Details
Main Authors: Robin van der Lee, Qian Feng, Martijn A Langereis, Rob Ter Horst, Radek Szklarczyk, Mihai G Netea, Arno C Andeweg, Frank J M van Kuppeveld, Martijn A Huynen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4618338?pdf=render

Internet

http://europepmc.org/articles/PMC4618338?pdf=render

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