Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics

Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics

Abstract Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor (VEGF) compounds enhance the activity of subsequent antitumor therapy, but the mechanism of this potentiation is far from clear. The most widespread explanation is enhanced delivery of therapeu...

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Bibliographic Details
Main Authors: Ilaria Fuso Nerini, Marta Cesca, Francesca Bizzaro, Raffaella Giavazzi
Format: Article
Language:English
Published: BMC 2016-06-01
Series:Chinese Journal of Cancer
Subjects:
Combination therapies
Angiogenesis inhibitors
Drug delivery
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s40880-016-0123-1

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http://link.springer.com/article/10.1186/s40880-016-0123-1

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