Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm

Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm

Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. Preventing α-Synuclein aggregation is challenging because of the disordered nature of the protein and the stochastic nature of fibrillogenesis, but, at the same time, it is a...

Full description

Bibliographic Details
Main Authors: Samuel Peña-Díaz, Jordi Pujols, Francisca Pinheiro, Jaime Santos, Irantzu Pallarés, Susanna Navarro, María Conde-Gimenez, Jesús García, Xavier Salvatella, Esther Dalfó, Javier Sancho, Salvador Ventura
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
α-synuclein
protein aggregation
amyloid inhibitor
Parkinson’s disease
synucleinopathies
small molecules
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.588947/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.588947/full

Similar Items