Repurposing existing medications as cancer therapy: design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic cell transplantation

Repurposing existing medications as cancer therapy: design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic cell transplantation

Abstract Background Repurposing existing medications for antineoplastic purposes can provide a safe, cost-effective, and efficacious means to further augment available cancer care. Clinical and preclinical studies suggest a role for the ß-adrenergic antagonist (ß-blocker) propranolol in reducing rat...

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Bibliographic Details
Main Authors: Jennifer M. Knight, Stephanie A. Kerswill, Parameswaran Hari, Steve W. Cole, Brent R. Logan, Anita D’Souza, Nirav N. Shah, Mary M. Horowitz, Melinda R. Stolley, Erica K. Sloan, Karen E. Giles, Erin S. Costanzo, Mehdi Hamadani, Saurabh Chhabra, Binod Dhakal, J. Douglas Rizzo
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
ß-blocker
Propranolol
Feasibility
Repurposed drugs
Multiple myeloma
Hematopoietic cell transplantation
Online Access:http://link.springer.com/article/10.1186/s12885-018-4509-0

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http://link.springer.com/article/10.1186/s12885-018-4509-0

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