The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis

The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis

<b>Background:</b> The pro-apoptotic protein Siva-1 functions in both extrinsic and intrinsic cell death signaling; however, the exact contribution of the endogenous Siva-1 to DNA damage-induced apoptosis is unclear. Using cisplatin, a chemotherapeutic drug, to induce DNA damage and cel...

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Bibliographic Details
Main Authors: Barkinge John, Gudi Radhika, Sarah Hawkins, Chu Fei, Borthakur Alip, Prabhakar Bellur, Prasad Kanteti
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2009-01-01
Series:Journal of Carcinogenesis
Subjects:
Apoptosis
Bcl-2 family
cisplatin
cytochrome c
p53
Siva-1
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2009;volume=8;issue=1;spage=2;epage=2;aulast=Barkinge

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http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2009;volume=8;issue=1;spage=2;epage=2;aulast=Barkinge

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