LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis

LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis

Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) proteins and enzymes, especially fibrillary collagens, and represents a major cause of morbidity and mortality worldwide. Lysyl oxidases (LOXs) drive covalent crosslinking of collagen fibers, thereby promotin...

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Bibliographic Details
Main Authors: Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
liver macrophages
lysyl oxidase like 2 (LOXL2)
liver fibrosis
matrix metalloproteinases (MMPs)
matrix metalloproteinase-14 (MMP-14)
monocyte-derived macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00480/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00480/full

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