The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events

T cells are the key players of the adaptive immune response. They coordinate the activation of other immune cells and kill malignant and virus-infected cells. For full activation T cells require at least two signals. Signal 1 is induced after recognition of MHC/peptide complexes presented on antigen...

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Bibliographic Details
Main Authors: Nirdosh Dadwal, Charlie Mix, Annegret Reinhold, Amelie Witte, Christian Freund, Burkhart Schraven, Stefanie Kliche
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
T-cell activation
integrin signaling
ADAP/SKAP1/2
T cells
adaptive immunology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.703534/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.703534/full

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