Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma

Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma

The development of targeted therapeutics for neuroblastoma, the third most common tumor in children, has been limited by a poor understanding of growth signaling mechanisms unique to the peripheral nerve precursors from which tumors arise. In this study, we combined genetics with gene-expression ana...

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Bibliographic Details
Main Authors: Christopher S. Hackett, David A. Quigley, Robyn A. Wong, Justin Chen, Christine Cheng, Young K. Song, Jun S. Wei, Ludmila Pawlikowska, Yun Bao, David D. Goldenberg, Kim Nguyen, W. Clay Gustafson, Sundari K. Rallapalli, Yoon-Jae Cho, James M. Cook, Serguei Kozlov, Jian-Hua Mao, Terry Van Dyke, Pui-Yan Kwok, Javed Khan, Allan Balmain, QiWen Fan, William A. Weiss
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714008298

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http://www.sciencedirect.com/science/article/pii/S2211124714008298

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