In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5

In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5

The present study was aimed to further characterize the pharmacological profile of N-[4-(trifluoromethyl) benzyl]-4-methoxybutyramide (GET73), a putative negative allosteric modulator (NAM) of metabotropic glutamate subtype 5 receptor (mGluR5) under development as a novel medication for the treatmen...

Full description

Bibliographic Details
Main Authors: Sarah Beggiato, Andrea C. Borelli, Maria C. Tomasini, M. Paola Castelli, Nicholas Pintori, Roberto Cacciaglia, Antonella Loche, Luca Ferraro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
intracellular calcium
CREB
Inositol trisphosphate
alcohol dependence
mGluR5
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00327/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00327/full

Similar Items