Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

Objective: Recent studies suggest that excess dietary fructose contributes to metabolic dysfunction by promoting insulin resistance, de novo lipogenesis (DNL), and hepatic steatosis, thereby increasing the risk of obesity, type 2 diabetes (T2D), non-alcoholic steatohepatitis (NASH), and related como...

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Bibliographic Details
Main Authors: Jemy A. Gutierrez, Wei Liu, Sylvie Perez, Gang Xing, Gabriele Sonnenberg, Kou Kou, Matt Blatnik, Richard Allen, Yan Weng, Nicholas B. Vera, Kristin Chidsey, Arthur Bergman, Veena Somayaji, Collin Crowley, Michelle F. Clasquin, Anu Nigam, Melissa A. Fulham, Derek M. Erion, Trenton T. Ross, William P. Esler, Thomas V. Magee, Jeffrey A. Pfefferkorn, Kendra K. Bence, Morris J. Birnbaum, Gregory J. Tesz
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Metabolism
Subjects:
Fructose
KHK
Insulin resistance
NAFLD
Metabolic disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000363

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http://www.sciencedirect.com/science/article/pii/S2212877821000363

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