HIV-1 adaptation to NK cell-mediated immune pressure.

The observation, by Alter et al., of the enrichment of NK cell "escape" variants in individuals carrying certain Killer-cell Immunoglobulin-like Receptor (KIR) genes is compelling evidence that natural killer (NK) cells exert selection pressure on HIV-1. Alter et al hypothesise that varian...

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Bibliographic Details
Main Authors: Marjet Elemans, Lies Boelen, Michael Rasmussen, Søren Buus, Becca Asquith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5472325?pdf=render