Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells[S]

Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells[S]

High levels of saturated FAs (SFAs) are acutely toxic to a variety of cell types, including hepatocytes, and have been associated with diseases such as type 2 diabetes and nonalcoholic fatty liver disease. SFA accumulation has been previously shown to degrade endoplasmic reticulum (ER) function lead...

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Bibliographic Details
Main Authors: Alexandra K. Leamy, Robert A. Egnatchik, Masakazu Shiota, Pavlina T. Ivanova, David S. Myers, H. Alex Brown, Jamey D. Young
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Journal of Lipid Research
Subjects:
saturated fatty acids
lipoapoptosis
nonalcoholic fatty liver disease
endoplasmic reticulum stress
phospholipid metabolism
membrane composition
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352524

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http://www.sciencedirect.com/science/article/pii/S0022227520352524

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