Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity

Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity

Abstract Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotrans...

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Bibliographic Details
Main Authors: Vladislav Volarevic, Bojana Djokovic, Marina Gazdic Jankovic, C. Randall Harrell, Crissy Fellabaum, Valentin Djonov, Nebojsa Arsenijevic
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Biomedical Science
Subjects:
Cisplatin
Nephrotoxicity
Acute kidney injury
Apoptosis
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12929-019-0518-9

Internet

http://link.springer.com/article/10.1186/s12929-019-0518-9

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