Mitochondrial ATP Depletion Disrupts Caco-2 Monolayer Integrity and Internalizes Claudin 7

Mitochondrial ATP Depletion Disrupts Caco-2 Monolayer Integrity and Internalizes Claudin 7

Objective:In vivo studies suggest that intestinal barrier integrity is dependent on mitochondrial ATP production. Here, we aim to provide mechanistic support, using an in vitro model mimicking the oxidative in vivo situation.Methods: Human Caco-2 cells were cultured for 10 days in culture flasks or...

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Bibliographic Details
Main Authors: Lonneke M. JanssenDuijghuijsen, Sander Grefte, Vincent C. J. de Boer, Lara Zeper, Dorien A. M. van Dartel, Inge van der Stelt, Melissa Bekkenkamp-Grovenstein, Klaske van Norren, Harry J. Wichers, Jaap Keijer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Physiology
Subjects:
Caco-2
permeability
mitochondria
intestinal epithelium
galactose
tight junctions
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00794/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00794/full

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