Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Abstract Background With ever-increasing exposure to engineered nanomaterials (NMs), there is an urgent need to evaluate the probability of consequential adverse effects. The potential for NM translocation to distal organs is a realistic prospect, with the liver being one of the most important targe...

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Bibliographic Details
Main Authors: Ali Kermanizadeh, Trine Berthing, Ewa Guzniczak, Melanie Wheeldon, Graeme Whyte, Ulla Vogel, Wolfgang Moritz, Vicki Stone
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Particle and Fibre Toxicology
Subjects:
3D primary human multi-cellular liver microtissue
Kupffer cells
In vitro hepatotoxicology
In vitro vs. in vivo comparisons
Online Access:http://link.springer.com/article/10.1186/s12989-019-0326-0

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http://link.springer.com/article/10.1186/s12989-019-0326-0

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