Class I histone deacetylase inhibition promotes CD8 T cell activation in ovarian cancer

Class I histone deacetylase inhibition promotes CD8 T cell activation in ovarian cancer

Abstract Objective Patients with epithelial ovarian cancer (EOC) typically present with late‐stage disease, posing a significant challenge to treatment. Although taxane and platinum‐based chemotherapy plus surgical debulking are initially effective, EOC is marked by frequent recurrence with resistan...

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Bibliographic Details
Main Authors: Tyler R. McCaw, Nidhi Goel, Dewey J. Brooke, Ashwini A. Katre, Angelina I. Londoño, Haller J. Smith, Troy D. Randall, Rebecca C. Arend
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Cancer Medicine
Subjects:
epigenetics
gynecological oncology
immunology
tumor‐infiltrating immune cells
Online Access:https://doi.org/10.1002/cam4.3337

Internet

https://doi.org/10.1002/cam4.3337

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