Synedrella nodiflora Extract Depresses Excitatory Synaptic Transmission and Chemically-Induced In Vitro Seizures in the Rat Hippocampus

Synedrella nodiflora Extract Depresses Excitatory Synaptic Transmission and Chemically-Induced In Vitro Seizures in the Rat Hippocampus

Extracts of the tropical Cinderella plant Synedrella nodiflora are used traditionally to manage convulsive conditions in the West African sub-region. This study sought to determine the neuronal basis of the effectiveness of these plant extracts to suppress seizure activity. Using the hippocampal sli...

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Bibliographic Details
Main Authors: Patrick Amoateng, Thomas A. Tagoe, Thomas K. Karikari, Kennedy K. E Kukuia, Dorcas Osei-Safo, Eric Woode, Bruno G. Frenguelli, Samuel B. Kombian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
hippocampal slices
field excitatory postsynaptic potentials
adenosine
SNE
seizure
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.610025/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.610025/full

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