Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.

Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.

Simvastatin, a HMG-CoA reductase inhibitor, is prescribed worldwide to patients with hypercholesterolemia. Although simvastatin is well tolerated, side effects like myotoxicity are reported. The mechanism for statin-induced myotoxicity is still poorly understood. Reports have suggested impaired mito...

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Bibliographic Details
Main Authors: Robert Smith, Rigmor Solberg, Linn Løkken Jacobsen, Anette Larsen Voreland, Arild Christian Rustan, G Hege Thoresen, Harald Thidemann Johansen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3885717?pdf=render

Internet

http://europepmc.org/articles/PMC3885717?pdf=render

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