EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.

TRAIL is a death receptor ligand that induces cell death preferentially in tumor cells. Recombinant soluble TRAIL, however, performs poorly as an anti-cancer therapeutic because oligomerization is required for potent biological activity. We previously generated a diabody format of tumor-targeted TRA...

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Bibliographic Details
Main Authors: Yvonne Möller, Martin Siegemund, Sven Beyes, Ricarda Herr, Daniele Lecis, Domenico Delia, Roland Kontermann, Tilman Brummer, Klaus Pfizenmaier, Monilola A Olayioye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4157814?pdf=render

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http://europepmc.org/articles/PMC4157814?pdf=render

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